Numerous studies have also found differences in the levels of trophic factors of the neurotrophin family (mainly brain-derived neurotrophic factor (BDNF)) and cytokines (such as interleukins (e.g., IL-6, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-18) and tumor necrosis factor alpha (TNF-α)), as well as the influence of oxidative stress mediators in BD patients compared to healthy controls [55,56]. The gene discussed is TNF; the disease is Behcet disease.