IDH2 and acute myeloid leukemia: Figure 1 shows the frequencies of the most relevant mutations described for AML, which affect the following genes: Fms-Like Tyrosine Kinase 3 (FLT3) [11], KIT [12], RAS [13], Nucleophosmin 1 (NPM1) [14], CCAAT Enhancer Binding Protein α (CEBPA) [2], Runt-related transcription factor (RUNX1) [12], DNA methyltransferase 3A (DNMT3A) [15], Isocitrate dehydrogenase (IDH) [12], Ten–eleven translocation 2 (TET2) [2], Additional sex comb-like 1 (ASXL1) [2], Wilms’ tumor 1 (WT1) [12], and Tumor protein 53 (TP53) [2].