Heightened TG2 expression was observed in patients with decreased eGFR; it was the highest in the CKD 4, 5 group (3.39 ± 0.54% vs. 6.89 ± 0.86% vs. 8.55 ± 1.02% vs. 12.89 ± 1.11%, Figure 2b,c, left panel). Here, TGM2 is linked to chronic kidney disease.