Severe COVID-19 is associated with increased levels of procoagulant factors, including Von Willebrand factor (VWF) [11,12], vascular cell adhesion markers [12,13,14,15], increased thromboelastography (TEG) parameters [4,16,17], and increased circulating soluble thrombomodulin (sTM) [12,18,19], which is a cleaved product of the full length thrombomodulin (TM) from the endothelial surface during inflammation [20]. The gene discussed is THBD; the disease is COVID-19.