While the ANGPT2 inhibition of normal ANGPT1-TIE2 signaling probably has a role in endothelial dysfunction and coagulopathy, it was also shown in vitro that ANGPT2, and to a lower extent ANGPT1, can bind and inhibit the function of thrombomodulin (TM) [38]. This evidence concerns the gene ANGPT1 and endothelial dysfunction.