Since wild-type p53, WTp53, is kept at a low level in health cells under normal conditions [9], in most cases, it causes an overexpression of p53 which is visualized by positive immunostaining corresponds to mutation(s) in Tp53/p53 [4]; however, it has also been suggested that the observed overexpression of p53 in RCC concerns the wild-type, and an increased level of WTp53 protein is associated with reduced overall survival [42]. This evidence concerns the gene TP53 and renal cell carcinoma.