Knockdown of SNHG16 in multiple myeloma cells suppressed cell proliferation, induced cell arrest and promoted the apoptosis via inducing cleaved-Caspase-3, cleaved-Caspase-9, Foxa3a and Bax expression, while inhibiting CCND1, Bcl-2, Cyclin D1, PI3K and p-AKT. Here, CASP3 is linked to plasma cell myeloma.