Figure 2 summarizes some of the most interesting pathways that could be regulated by RUNX1 in the context of promotion of IR in NAFLD, including the modulation of genes such as CCAAT/enhancer-binding protein alpha (CEBPA), histone deacetylase 1 (HDAC1), the transcription factor c-JUN, nuclear factor kappa B (NFκB), and some types of protein kinase C (PKCβ and PKCε). Here, NFKB1 is linked to metabolic dysfunction-associated steatotic liver disease.