RUNX1 and metabolic dysfunction-associated steatotic liver disease: In this sense, when we performed an ANN analysis concerning the probability of the relationship between RUNX1 protein and NAFLD motives, our first main finding is that RUNX1 seems to show a medium intensity relationship with both motives–hepatic IR and lipotoxicity–and a high intensity relationship with hepatic injury and liver fibrosis motives, suggesting that this protein probably plays a role in these processes.