Its activation can be induced by TNF-α and JNK mechanisms [75,76] and can lead to the up-regulation of TNF-α, IL-6 and neutrophil gelatinase-associated lipocalin (LCN-2), contributing to IR-related processes in NAFLD [48,73,77,78]. This evidence concerns the gene LCN2 and metabolic dysfunction-associated steatotic liver disease.