Moreover, engineered fetal forebrain NSCs leading to glioma-like cells (gathering H3.3G34R, TP53 KO, and PDGFRA overexpression) were shown to upregulate key transcription factors involved in neuroprogenitor self-renewal and proliferation, such as OLIG2 and SOX3, and in forebrain-specific markers, including DMRTA2, EMX2, NR2F1 and HIVEP2 [82,85,86,87,88]. This evidence concerns the gene TP53 and central nervous system cancer.