GHRHR and hyperandrogenism: A general DNA methylome profiling of GCs recently has revealed an altered methylation in genes regulating pivotal ovarian functions in PCOS [66]: in particular, few differentially methylated genes, including aldo-keto reductase family 1 member C3, calcium-sensing receptor, growth hormone-releasing hormone receptor and tumor necrosis factor, which predominantly contribute to hyperandrogenism, premature luteolysis and oocyte development defects, can be explored as novel epigenetic candidates in mediating ovarian dysfunction.