In murine models, DNA hypomethylation regulates the expression of several key genes for developing PCOS; the same genes, involved in DNA demethylation (TET1), axon guidance (ROBO-1), inhibition of cell proliferation (CDKN1A), inflammation (HDC) and insulin signaling (IGFBPL1, IRS4), are found to be hypomethylated in PCOS women as well, and it has been suggested that this epigenetic process could be inheritable, since three of them (ROBO-1, HDC, IGFBPL1) resulted in being hypomethylated in daughters suffering from PCOS [65]. Here, IRS4 is linked to polycystic ovary syndrome.