FSHR and polycystic ovary syndrome: The FSHR (follicle-stimulating hormone receptor) gene also showed polymorphisms in PCOS women: interestingly, the two detected missense mutations, p.Ala307Thr and p.Asn680Ser, negatively affect ovarian FSH response, causing an impaired oocyte maturation, anovulation and consequent infertility [54].