Interestingly, the hyperandrogenic profile differs between PCOS obese and nonobese women, and the discrepancy occurs under the influence of an epigenetic control: in particular, the gene that encode for luteinizing hormone receptor (LHR) is overexpressed in PCOS nonobese women; in contrast, the insulin receptor gene (INSR) in under expressed in PCOS obese subjects [82]. This evidence concerns the gene LHCGR and polycystic ovary syndrome.