PLOD1 and polycystic ovary syndrome: In this regard, dietary patterns that include large fiber consumption seem able to improve PCOS clinical manifestations just acting on gut microbiota; into specifics, a recent study has reported that a 12-week high-fiber diet, or in combination with Acarbose, favors Lactobacillus and Bifidobacterium abundance with a positive effect on LH/FSH ratio, testosterone, homeostasis model assessment-insulin resistance (HOMA-IR), α-1-acid glycoprotein (α-AGP) and leptin [147].