The epigenetic regulation affects also the Traf2- and Nck-interacting kinase (TNIK) usually involved in cell proliferation: the hypermethylation of the corresponding gene upregulates TNIK in PCOS ovarian tissue; moreover, the hyperexpression of TNIK seems to be related to Wnt signaling pathways, finally altering women metabolic profile [61]. This evidence concerns the gene TNIK and polycystic ovary syndrome.