VEGFA and hepatocellular carcinoma: Data from in vitro models demonstrated that the evasion of intrinsic immune system pathways such as the overexpression of vascular endothelial growth factor (VEGF), upregulation of myeloid-derived suppressor and regulatory T (Treg) cells, and suppression of NK-T cells have been implicated in the tumorigenesis of HCC, making anti-VEGF agents and immune check point inhibitors attractive options in HCC [1].