CXCR4 and Wilson disease: Therefore, in the present study, it could be speculated that the presence of increased miR-222 levels in the MG of WD animals compared with both control and Rev animals, accompanied by the presence of lower mRNA Cxcr4 levels in comparison with the Rev group, could contribute to a proinflammatory and insulin resistance state in these dams, and would be in accordance with the presence of elevated plasma insulin levels, as previously described [19].