INS and obesity due to melanocortin 4 receptor deficiency: Interestingly, the fact that miR-222 levels and the mRNA levels of its target gene Cxcr4 were restored in the MG of obese dams fed an SD during lactation supports the relevance of this miRNA and interest in a nutritional intervention during lactation as a strategy to prevent such alterations in the MG associated with dietary obesity and, in turn, the proinflammatory and insulin-resistant states in these dams.