Motoko et al., have previously reported that uncontrolled autophagy may play an important role in the pathogenesis of PBC by causing autoimmune processes through aberrant expression of mitochondrial antigens such as the pyruvate dehydrogenase complex, E2 (PDC-E2) and promoting cellular senescence in BECs in the biliary tract in PBC [41,43,44]. This evidence concerns the gene DLAT and primary biliary cholangitis.