According to this, an affective ‘Apelin Cardiac Fibroblast Signaling Pathway’ (ratio—0.455; z-score—−2.333; p-value—5.67× 10−4), which means the activation of cardiac fibroblasts and their differentiation into myofibroblasts and causes the formation of cardiac fibrosis, leading to heart failure, and ‘Remodeling of Epithelial Adherents Junctions’ (ratio—0.382; z-score—2.449; p-value—1.71 × 10−5), ‘Inhibition of Matrix Metalloproteases’ (ratio—0.344; z-score—−1.265; p-value—4.57× 10−3), or ‘TGF-β Signaling’ (ratio—0.218; z-score—1.5; p-value—4.86× 10−2) were found in dataset (Figure S1A). The gene discussed is APLN; the disease is heart failure.