Moreover, a previous study indicated that increased m7G modifications of a subset of tRNAs by the METTL1/tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit (WDR4) complex stabilizes mRNAs, increases the translation efficiency, reduces ribosome pausing, and is associated with poor survival in human cancers [93]. This evidence concerns the gene METTL1 and cancer.