In conclusion, gene regulation by H3K27 acetylation is involved in uterine leiomyoma pathogenesis through processes such as cell proliferation, cell signaling and cell transport, angiogenesis, ECM, Wnt and TGFβ pathway, and reversal of this acetylation could offer a therapeutic option for patients with uterine leiomyomas. This evidence concerns the gene TGFB1 and Uterine leiomyoma.