AR and glucocorticoid resistance: The association of the rs143711342 and rs56149945 GR polymorphisms (having generalized glucocorticoid resistance) and the rs5522 MR polymorphism (with higher activity than the normal isoform) may produce a synergistic effect that increases MR signaling through the interaction of the mutated MR with a new coregulatory partner released as a result of enzalutamide-induced inhibition of the AR (Figure 3).