GRIA1 and Hyperammonemia: In rats with chronic hyperammonemia and additional neuroinflammation due to insertion of canula into the cerebral ventricle, Cabrera-Pastor et al. [18] propose that increased levels of TNFα enhance membrane expression of GluA1 and reduces that of GluA2 while increased levels of IL-1β increase membrane expression of NR1 and NR2A.