When the patients were grouped according to presence or absence of tumor, CSF-NFL levels were significantly increased in the patients with tumors (median: 6248, range: 1003–10,000) compared to those without (median: 1480, range: 87–10,000; p = 0.0007) and the controls (median: 1029, range: 502–3346; p = 0.0002) (Figure 1B). The gene discussed is NEFL; the disease is neoplasm.