Lastly, the NLRP3 inflammasome contributes to the development of myeloid leukemias, where its activation has been found in chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML), and acute myeloid leukemia (AML) patients harboring KRAS mutations [97,98]. This evidence concerns the gene KRAS and juvenile myelomonocytic leukemia.