Lastly, the NLRP3 inflammasome contributes to the development of myeloid leukemias, where its activation has been found in chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML), and acute myeloid leukemia (AML) patients harboring KRAS mutations [97,98]. Here, NLRP3 is linked to acute myeloid leukemia.