MAPT and cerebrovascular disorder: Robust evidence is available showing that Aβ, tau, and cerebrovascular disease are individually and in combination associated with microscopic neuronal changes (e.g., shrinking dendritic tree, decreasing synaptic density, and demylenation), as well as microscopic structural brain changes demonstrated in histological and neuroimaging studies (e.g., total and regional brain volume shrinkage, decrease structural connectivity, widening sulcal width, and increased ventricular and cerebrospinal volume [3,15,16].