MANF and neurodegenerative disease: Upregulation of KDELRs could potentially be useful in neurodegenerative disease and after an ischemic attack to retain ER proteins and ensure the protective effects exerted by factors such as cardiomyokine cerebral dopamine neurotrophic factor (CDNF) or mesencephalic astrocyte-derived neurotrophic factor (MANF) that bind KDELR itself on the plasma membrane [58,59].