Breastfeeding appears to influence global methylation patterns, modulate epigenetic effects of some genetic variants and be negatively associated with promoter methylation of the leptin (LEP) (an anorexigenic hormone that regulates growth, hunger and insulin sensitivity), CDKN2A (implicated in tumor suppression) and Slc2a4 (which encodes an insulin-related glucose transporter) genes and positively associated with promoter methylation of Nyp gene (which produces an orexigenic neuropeptide) [732]. Here, LEP is linked to neoplasm.