ADK and hepatocellular carcinoma: Thus, the exposure of the HepG2 cells to IC50 of TetraVV and cisplatin for 24 h showed that TetraVV induced a 2.6-fold increase in AK release (p < 0.0001) in the cell media of liver carcinoma compared to control cells, while a 2-fold increase (p < 0.0001) in AK release was observed for cisplatin (Figure 5B).