Furthermore, aseptic behavior, the proper nutrition of malnourished patients; systematic education and control of medical personnel; and cautious use PPIs, limiting them to situations where they are necessary, especially in patients with low albumin concentration, ANSS, and advanced CKD, could significantly reduce CDI-associated morbidity and mortality among adults, particularly those with CKD. The gene discussed is ALB; the disease is clostridium difficile infection.