It has recently been proposed that Aβ can be considered an AMP; thus, representing a type of innate immune defense protein that protects the host from a variety of pathogens [22,39,40] and that other proteins with antimicrobial activity, such as α- and β-defensins, lactoferrin, cystatins A and B, histatin 1, statherin, and thymosin β4 play a key role in AD [41,42,43,44,45]. The gene discussed is STATH; the disease is Alzheimer disease.