NOS2 and pancreatic adenocarcinoma: Our preliminary findings obtained by gene microarray analysis of a CD133+/CD44+ CSC population isolated from the pancreatic adenocarcinoma (PDAC) cell lines PANC1 and MiaPACA2 revealed a strong iNOS mRNA induction in MiaPaca2-derived CSCs compared to non-SC population (CD133-/CD44-), whereas in PANC1 CSCs, iNOS was significantly inhibited (Figure 3).