Nevertheless, future studies are warranted, to delve into the association between T2D and thyroid dysfunction; these should explore common molecular and cellular mechanisms that may play a role in both conditions, how Se fits into this relationship, and whether Se supplementation (allowing for full selenoprotein activity and avoiding toxic consequences) may contribute to the prevention and/or therapeutic treatment of these globally widespread conditions. The gene discussed is SELENOS; the disease is type 2 diabetes mellitus.