Moreover, in a model of SELENOV knockout mice, SELENOV emerged as a new inhibitor of body-fat accumulation, activator of energy expenditure, and regulator of O-GlcNAcylation (a protein associated with various metabolic diseases including T2D and obesity), and as such, is an interesting protein to be further investigated in the future [157] (Table 2). Here, SELENOV is linked to obesity due to melanocortin 4 receptor deficiency.