In consistent with our previous results that emodin protects the intestine from oxidative stress impairment [1,17,18], we demonstrate emodin alleviates morphological impairment, fatty acid metabolic disorder, antioxidant disorder, and cell fate determination by targeting Notch-Nrf2 crosstalk in the liver of M. amblycephala. Here, NFE2L2 is linked to inherited fatty acid metabolism disorder.