CYBB and type 2 diabetes mellitus: Further work also suggested a contribution of Nox2/ROS signaling to the development of neuropathic pain in a model of type 2 diabetes, as Nox2 expression was induced in the spinal cord of type 2 diabetic rats and treatment with the ROS scavenger α-phenyl-N-tert-butyl nitrone attenuated diabetic neuropathic pain behavior in response to mechanical and thermal stimuli [26].