NOX4 and Hyperglycemia: In line with this, action potential firing in DRG neurons after peripheral nerve injury was reduced in the absence of Nox4 [27], and the inhibition of Nox4 by GKT137831 in a model of hyperglycemia-induced neurophysiological disorders restored expression of peripheral myelin proteins and prevented sensorimotor defects in mice, further suggesting a contribution of Nox4 in diabetes-induced peripheral neuropathy [118].