In fact, it has been shown that the expression of the first rate-limiting enzyme of glycolysis, hexokinase 2 (HK2), is elevated in the RA synovial tissue, as well as that its overexpression in the synovial lining of a preclinical model promotes hypertrophy of healthy synovium and an aggressive synovial phenotype. This evidence concerns the gene HK2 and rheumatoid arthritis.