In addition to this, polymorphisms and expression of inflammasome genes are associated with susceptibility, disease activity and anti-TNF treatment response in RA [172,173,174], while it has also been described how several microRNA (miR-33, miR-20a and miR-30a) act as positive regulator of the NLRP3 inflammasome in RA macrophages [175,176,177]. Here, TNF is linked to rheumatoid arthritis.