Compelling evidence has described that NLRP3 inflammasome, and in turn IL-1β secretion, are highly activated in both RA patients and arthritis preclinical models in several type of RA cells (macrophages or monocytes, CD4+T cells, Th17 and synoviocytes) [48,158,159,160,161]. Here, CD4 is linked to rheumatoid arthritis.