In RA, the transcription factor NF-κB is highly activated and represents one of the main inflammatory mediators since it is involved in the induction of numerous pro-inflammatory cytokines such as IL-1β, IL-6, IL-8 or TNF-α in monocytes, macrophages and also in synoviocytes [22,23,141]. This evidence concerns the gene IL1B and rheumatoid arthritis.