Our results are in line with this latter evidence, in identifying Lyc W as a pro-apoptotic factor of the A549 cell line, that increases either the nuclear expression of the redox-sensitive transcription factors NF-κB, or both the m-RNA and protein level of IL-8, further supporting the chemopreventive role that lycopene can have in lung cancer, through its pro-oxidant and pro-inflammatory activity. The gene discussed is CXCL8; the disease is lung cancer.