Transgenic-adipo-PGC-1α mice displayed reduced adipocyte hypertrophy, associated with a reduction in molecules within the TGF-β signaling pathway, and of the inflammatory markers nephroblastoma-overexpressed/cellular communication network factor 3 (NOV/CCN3), Twist1, and IL-6. The gene discussed is PPARGC1A; the disease is Nephroblastoma.