In the present study, the specific PGC-1α overexpression in adipocytes was sufficient to ameliorate liver steatosis and reduce the NAFLD activity score (N.A.S.)in obese mice, suggesting a paracrine or endocrine influence of adipocyte PGC-1α in improving liver function and morphology. This evidence concerns the gene PPARGC1A and metabolic dysfunction-associated steatotic liver disease.