Furthermore, FFA, transformed into diacylglycerol molecules, can substantiate insulin resistance by activating the signaling cascades of the serine kinases Protein Kinase C-ε (PKCε) and c-Jun-N-terminal kinase (JNK), which hamper insulin receptor activation and subsequent signal transmission by insulin receptor substrates 1 and 2 (IRS1, IRS2) [95,130,131]. Here, INSR is linked to Insulin resistance.