Certain genetic mutations causing dysfunction of ABCR are responsible for increasing the susceptibility of such retina to light-induced injury shown in animals and are associated with development of Stargardt’s disease and a subset of cases of other blinding diseases, retinitis pigmentosa and age-related macular degeneration (AMD) in humans [4,15,16]. This evidence concerns the gene ABCA4 and age-related macular degeneration.