Overall, antioxidant therapeutic strategies in cancer can be classified as targeting ROS with nonenzymatic antioxidants, including NRF2 activators [108], vitamins [109,110] (Figure 3) or targeting ROS with enzymatic antioxidants, including NOX inhibitors [18,111], SOD mimics [112], NAC and GSH esters (Figure 4) (Table 1) [113,114]. Here, SOD1 is linked to cancer.