Consequently, it is not surprising that halofuginone (an inhibitor of the TGF-β signaling pathway) and bevacizumab (an anti-VEGF antibody) have been shown to prevent or reduce radiation-induced fibrosis [281,282], with the additional advantage of inhibiting tumor angiogenesis and consequently tumor growth and metastasis formation. The gene discussed is TGFB1; the disease is neoplasm.