PDE6B and retinitis pigmentosa 1: Other factors, including a high-fat diet, can worsen the disease progression in rd10 mice (a model of autosomal RP whose mutation in phosphodiesterase 6 (PDE6b) is the same as that found in patients with RP) through the increased expression of inflammatory mediators such as glycogen synthase kinase-3β (GSK-3β), NF-κB and IL-6, phospho-STAT3/STAT3 and IL-1α [35].