Yet in two known studies concerning neuronal cells (PC12 cells rat pheochromocytoma, retinal ganglion cells), exposure to saffron compounds elicited similar patterns of BCL2 and Bax expression, as to our study, i.e., Bcl-2 upregulation and Bax downregulation, protecting cells against oxidative stress-induced cell apoptosis [186,187]. Here, BAX is linked to hereditary pheochromocytoma-paraganglioma.