Overall, our results agree with three possible pathways via which CRCs and DMCRT exert their cytotoxicity on glioblastoma and rhabdomyosarcoma cell lines: (a) enhancement of BAX and BID -mediated cellular apoptosis; (b) suppression of MYCN and BCL-2 cellular survival; and (c) suppression of the expression of GSTM1 and SOD1 oxidative species scavengers. The gene discussed is MYCN; the disease is rhabdomyosarcoma.