The cardiac phenotypes of cardiac-specific Nox4 KO and systemic Nox4 KO were also observed to differ in terms of the effect of pressure overload: cardiac-specific Nox4 KO attenuates cardiac hypertrophy after transverse aortic constriction (TAC), whereas systemic Nox4 KO does not exhibit a protective effect [34]. The gene discussed is NOX4; the disease is cardiac hypertrophy.