In addition, considering that PON1 also has a pivotal role in protection against bacterial endotoxins through detoxification of lipid peroxides [110] and that OM is a bone inflammation due to bacterial infection (e.g., Staphylococcus aureus) and/or exposure to bacterial toxins [111], Koruk suggested that the low PON1 activity might be related to the drastic loss in protection against bacterial endotoxins, and subsequently to a far worse prognosis. Here, PON1 is linked to bacterial infectious disease.