PNPLA3 and metabolic dysfunction-associated steatotic liver disease: The PNPLA3 polymorphism rs738409 C>G encoding for the I148M protein is the most robust and well-replicated genetic variant associated with NAFLD [27], alcoholic fatty liver disease (AFLD), NASH [29], and severe alcohol-related steatohepatitis (ASH) [28] and is related to TG accumulation, lipid droplet remodeling, and lipotoxicity [30].