PYGO1 and metabolic dysfunction-associated steatotic liver disease: Recently, a GWAS identified a new signal on chromosome 15 (rs11858624) in the Pygopus family PHD finger 1 (PYGO1) gene, a novel steatosis modifier that contributes to the Wnt signaling pathway, suggesting that Wnt signaling pathways may be relevant in NAFLD/NASH pathogenesis [33].