NFKB1 and male infertility: Therefore, the detection of HR-HPV infection genotypes, pro-inflammatory cytokines and OS biomarkers may be useful complementary tools for male infertility diagnosis, even to propose new perspectives on its pathogenesis (NF-kB and NRF-2), therapeutic approaches (vaccines, antiviral, immunomodulators and antioxidants) and the prevention of the development of other diseases.