MAP2K7 and cancer: Previous researchers reported that human miR-493 was an important regulator for colon [43] and bladder [44] cancers as it targeted genes’ insulin-like growth factor receptor (IGF1R), MAP kinase kinase 7 (MKK7), ras homolog family member C (RhoC), and frizzled class receptor 4 (FZD4) with central roles in these cancers.