Using this model with SFD lines carrying the TIMP3 disease‐causing variant, the authors showed that choriocapillaris atrophy and choroidal neovascularization at the RPE‐choriocapillaris interface preceded drusen formation and ECM thickening,37 which thus brings confirmation on the chronology of SFD progression. The gene discussed is TIMP3; the disease is Sorsby fundus dystrophy.