VWF and infection: For example, lactate indicates tissue hypoxia, PCT indicates infection, CRP and cytokines indicate inflammation, thrombomodulin, thrombin-antithrombin complex and D-dimers indicate coagulation, angiopoietin-2 and von Willebrand Factor indicate endothelial injury, and HLA-DR on monocytes indicate immunosuppression [8, 36, 37].