The injection of AD-tau seeding resulted in the progressive development of AT8-positive pathology in NL-G-F-tau animals injected at 3 months of age, from 1 to 5 m.p.i (Fig. 2a, b) and in NL-G-F-tau animals injected at 6 months of age from 1 to 5 m.p.i (Fig. 2c, d) in the isocortex and entorhinal area. Here, MAPT is linked to Alzheimer disease.