Notably, the attenuated weight gain and metabolic benefits attributed to RYGB microbiota transfer were clearly compromised in Gly-MCA-treated and in Tgr5−/− mice, suggesting that intestinal FXR and subsequent systemic TGR5 activation may play an important role in mediating selective aspects of RYGB microbiota transfer on improved energy homeostasis and metabolic control in HF-DIO recipients. Here, GPBAR1 is linked to hydrops fetalis.