NR1H4 and hydrops fetalis: Suppression of intestinal FXR signaling by Gly-MCA (Fig. 7a) diminished the beneficial effects of RYGB microbiota on improved adiposity (Fig. 7b–d) and glucose homeostasis (Fig. 7e, f) without compromising energy and glucose control in HF-DIO control mice (Supplementary Figure S9).