In agreement with our results, specific intestinal FXR activation by 6-ethyl-chenodeoxycholic acid in rats and by fexaramine in mice [40] has previously been shown to protect against the development of obesity and glucose intolerance, which was associated with enhanced thermogenesis and increased browning of WAT depots [40]. The gene discussed is NR1H4; the disease is obesity due to melanocortin 4 receptor deficiency.