Among them, HIF1A may indirectly activate NLRP3, which encodes for NLRP3 inflammasomes, contributing to the inflammatory responses via IL-1β activation, which is down-regulated to a greater extent in BPD-DS in this study, and could be of key importance in the development of type 2 diabetes [62]. The gene discussed is HIF1A; the disease is type 2 diabetes mellitus.