On the other hand, adipocyte size change did not show a significant impact on total remission rates (OR = 0.95; 95%CI = 0.86–1.02; p = 0.19) (Fig. 6B), nor on type 2 diabetes or dyslipidemia remission, and was only significantly associated with four DEGs, all of them being down-regulated DEGs exclusive to BPD-DS: INSYN1 (r2 = 0.68), SRXN1 (r2 = 0.65), CORO1C (r2 = 0.65) and SNPH (r2 = 0.64) (Fig. 6B). Here, INSYN1 is linked to metabolic syndrome.