For instance, metadherin has the potential to function as a diagnostic and prognostic marker in CRC [32]; neuropilin-1 and angiopoietin-2 serve as markers for hepatocellular carcinoma [33]; miR-150 expression can be used to predict imatinib response chronic myeloid leukemia patients [34]; and the expression of Oct4 is correlated with GC progression [35]. This evidence concerns the gene ANGPT2 and chronic myelogenous leukemia, BCR-ABL1 positive.