CRP and metabolic syndrome: However, in order to investigate whether genetic predisposition to lifelong higher CRP concentrations plays a role in mortality in persons with CRC, our study was limited in the sense that only genetic variants in the CRP gene could be included in the CRP-score, although there is evidence from genome-wide association studies that also SNPs in other loci, including those implicating pathways related to metabolic syndrome and immune system, are associated with circulating CRP [36].