Associations were not altered after excluding participants with CRP concentrations ≥ 10 mg/L (n = 99 excluded; CRC mortality HR 1.01, 95% CI 0.69, 1.46; all-cause mortality HR 0.94, 95% CI 0.67, 1.30), diabetics (n = 123 excluded; CRC mortality HR 1.01, 95% CI 0.71, 1.42; all-cause mortality HR 0.94, 95% CI 0.69,1.28) or participants with family history of CRC (n = 27 excluded; CRC mortality HR 0.93, 95% CI 0.67, 1.29; all-cause mortality HR 0.92, 95% CI 0.69, 1.24). The gene discussed is CRP; the disease is colorectal carcinoma.