One large Mendelian randomization study (30,480 CRC cases, 22, 844 controls) did not confirm that genetically determined (including CRP-associated SNPs both inside and outside the CRP gene) higher CRP concentrations are associated with higher CRC risk [12], while another recent Mendelian randomization study (10,142 women of whom 734 developed CRC) found associations between genetically determined CRP and CRC risk in subgroups of lifestyle factors, i.e. in non-viscerally obese and individuals with high-fat diet [13]. Here, CRP is linked to colorectal carcinoma.